Alternative delivery of a thermostable inactivated polio vaccine
نویسندگان
چکیده
منابع مشابه
Alternative delivery of a thermostable inactivated polio vaccine.
In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants, have the potential to deliver vaccines outside the cold-chain and administer them without t...
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OBJECTIVES To present an update on the status of poliomyelitis worldwide, number of cases per year, regions most affected by the disease, vaccines currently available, their risks and benefits, monovalent vaccine use, risks of disseminating a mutant virus in the community, progress that has been made in terms of worldwide eradication and the World Health Organization's (WHO) proposals in this t...
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Inactivated poliovirus vaccine (IPV) is efficacious against paralytic disease, but its effect on mucosal immunity is debated. We assessed the efficacy of IPV in boosting mucosal immunity. Participants received IPV, bivalent 1 and 3 oral poliovirus vaccine (bOPV), or no vaccine. A bOPV challenge was administered 4 weeks later, and excretion was assessed 3, 7, and 14 days later. Nine hundred and ...
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OBJECTIVE To analyze the costs of vaccination regimens for introducing inactivated polio vaccine in routine immunization in Brazil. METHODS A cost analysis was conducted for vaccines in five vaccination regimens, including inactivated polio vaccine, compared with the oral polio vaccine-only regimen. The costs of the vaccines were estimated for routine use and for the "National Immunization Days...
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In 2000, the island of Hispaniola, home to Haiti and the Dominican Republic, was the first place where the existence of circulating vaccine derived poliovirus (cVDPV) was demonstrated [1]. As a live product, oral polio vaccine (OPV), once excreted, could enter the environment, reassort with other enteroviruses, and produce cVDPV [2]. After the investigation of that outbreak, the first of a doze...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2015
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2015.03.011